Your scenario is a little unclear. When you say "I have the ISE open as admin" it can mean one of two things. 1) I am logged in with an account that is in an administrators group (local or domain). 2) I launched the ISE form the admin context (Run as Administrator, or from a console window that is already in the Admin context.
Simply doing #1 will get you access denied since UAC will run it in the lower privilege state. The way you can tell definitively is to run ...
In the lower state you will only have five privileges. In the higher state you will have upwards of 20 (actual count varies by OS).