I use a vbs script that calls an Powershell Gui script, which then displays a gui and we can begin a process. This works on 2008 servers, but we are not testing in a 2012 server and I am not able to get the vbscript to open the powershell gui. Is there a known issue with poweshell in 2012 or would this be an issue with the vbscript?
I don't know about a "known issue." There are certainly no "known problems." And I couldn't tell you about problems with VBScript on 2012 because I quite honestly have never run VBScript files on 2012 :).
What DOES happen? Nothing? An error message? Can you manually ru n the PowerShell script as a test?